Future direction of pre-implantation genetic diagnosis (PGD)

by Somjate Manipalviratn, M.D.| Superior A.R.T

Comparative Genomic Hybridization (CGH)

A significant proportion of unsuccessful pregnancy is caused by numerical chromosome imbalance or aneuploidy supported by the evidence that >50% of fif irst trimester abortuses are aneuploidy. FISH was introduced to reveal aneuploidy in embryos in order to improve the pregnancy success. However, whether PGD using FISH technique will improve pregnancy rate of IVF treatmentcycle is still controversial due to its limitation in the number of chromosome studied. This is limited by the number of distinct fluorochromes which are available to label the DNA probes.

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