Future direction of pre-implantation genetic diagnosis (PGD)

by Somjate Manipalviratn, M.D.| Superior A.R.T

Comparative Genomic Hybridization (CGH)

A significant proportion of unsuccessful pregnancy is caused by numerical chromosome imbalance or aneuploidy supported by the evidence that >50% of fif irst trimester abortuses are aneuploidy. FISH was introduced to reveal aneuploidy in embryos in order to improve the pregnancy success. However, whether PGD using FISH technique will improve pregnancy rate of IVF treatmentcycle is still controversial due to its limitation in the number of chromosome studied. This is limited by the number of distinct fluorochromes which are available to label the DNA probes.

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PGD-PCR success for VHL disease : A case report from Superior A.R.T.

by Piyaphan Punyatanasakchai, M.D. | Superior A.R.T.

Abstract : Von Hippel-Lindau (VHL) is a rare autosomal dominant genetic condition involving the abnormal growth of blood vessels result in little knots which are called angiomas or hemangioblastomas in some parts of the body which are particularly rich in blood vessels such as in the cerebellum, spinal cord, kidney and retina. These abnormal vessels usually occur in the retina. As a result, loss of visions is very common. Some of these tumors are benign, while others are cancerous.

There is a wide variation in the age of onset of the disease, the organ system affected and the severity of effect. This disease is caused by mutation of the Von Hipple-Lindau tumor suppressor (VHL) gene on the short arm of chromosome 3. About 80% of cases were inherited this mutation gene from one of their parents. ICSI and Preimplantation Genetic Diagnosis (PGD) with PCR technique is a method to avoid VHL gene transmission from the parents to the child. A 37 years old healthy woman and her 37 years old husband who has experienced multiple organ tumors from VHL has come to Superior ART to consult about their plan to have unaffected child(ren) since last year. They have one child, 2 years old, who also has got VHL mutated gene transmitted from his father.

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Making Dreams Come True: Superior A.R.T.

by PlacidWay | Superior A.R.T.
Overview
Assisted reproduction technology, more commonly known as ART, is a common approach to fertility and infertility issues around the world. However, few facilities are able to offer the variety of state-of-the-art treatments and technologies as Superior A.R. T., located in Bangkok, Thailand.

Treatments Offered
Superior A.R.T. offers a variety of treatments and state-of-the-art technologies to help couples achieve their dreams of having children. A few of the most common procedures and infertility treatments offered as Superior A.R.T.

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