Future direction of pre-implantation genetic diagnosis (PGD)

by Somjate Manipalviratn, M.D.| Superior A.R.T

Comparative Genomic Hybridization (CGH)

A significant proportion of unsuccessful pregnancy is caused by numerical chromosome imbalance or aneuploidy supported by the evidence that >50% of fif irst trimester abortuses are aneuploidy. FISH was introduced to reveal aneuploidy in embryos in order to improve the pregnancy success. However, whether PGD using FISH technique will improve pregnancy rate of IVF treatmentcycle is still controversial due to its limitation in the number of chromosome studied. This is limited by the number of distinct fluorochromes which are available to label the DNA probes.

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PGD-PCR success for VHL disease : A case report from Superior A.R.T.

by Piyaphan Punyatanasakchai, M.D. | Superior A.R.T.

Abstract : Von Hippel-Lindau (VHL) is a rare autosomal dominant genetic condition involving the abnormal growth of blood vessels result in little knots which are called angiomas or hemangioblastomas in some parts of the body which are particularly rich in blood vessels such as in the cerebellum, spinal cord, kidney and retina. These abnormal vessels usually occur in the retina. As a result, loss of visions is very common. Some of these tumors are benign, while others are cancerous.

There is a wide variation in the age of onset of the disease, the organ system affected and the severity of effect. This disease is caused by mutation of the Von Hipple-Lindau tumor suppressor (VHL) gene on the short arm of chromosome 3. About 80% of cases were inherited this mutation gene from one of their parents. ICSI and Preimplantation Genetic Diagnosis (PGD) with PCR technique is a method to avoid VHL gene transmission from the parents to the child. A 37 years old healthy woman and her 37 years old husband who has experienced multiple organ tumors from VHL has come to Superior ART to consult about their plan to have unaffected child(ren) since last year. They have one child, 2 years old, who also has got VHL mutated gene transmitted from his father.

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Fertility Options Abroad

by PlacidWay

A large number of fertility treatments are available to treat of wide variety of causes and issues that result in lack of conception.

Some of the most common fertility treatments include:

• Clomid treatments
• Ovulation Induction (OI)
• In vitro fertilization (IVF)
• Intracytoplasmic sperm injection (ICSI)
• Intrauterine insemination (IUI)

Treatment of prescribed medications and hormones to increase fertility in a process called ovulation induction is usually the first step toward conception through infertility treatments or therapy. Intrauterine insemination (IUI) is typically tried during the next stage of fertility treatment evaluation if ovulation therapy procedures don’t work. This technique is commonly known as artificial insemination.

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Successful pregnancy after preimplantation genetic diagnosis in a female with Sickle cell Anemia

by Superior A.R.T
I’d like to mention the case of a couple who carries Sickle Cells Anemia. They came to seek our advice of how to have an inherited disease free baby. This has led me come in contact with Superior A.R.T. center and its laboratory services to consult the possibility of PGD-PCR testing. It was a unique case since, as far as I am aware of, this was the first case ever of PGD-PCR testing for Sickle Cells Anemia in Thailand.

Discussing with scientists from Sydney IVF and Superior A.R.T. gave me such a high confidence in this center. Thanks to their prompt response, we were able to provide rapid advice about the most suitable treatment. Following the first talk with the patients, it took us only a few days after to contact Superior A.R.T. and prepare the whole process of treatment starting from Preparation for specific test. I was very impressed by their prompt and efficient services. And it is such a great delight that the treatment resulted in successful conception. She recently delivered a healthy baby girl with the birth weight of 3,700 grams by a cesarean delivery.

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Making Dreams Come True: Superior A.R.T.

by PlacidWay | Superior A.R.T.
Overview
Assisted reproduction technology, more commonly known as ART, is a common approach to fertility and infertility issues around the world. However, few facilities are able to offer the variety of state-of-the-art treatments and technologies as Superior A.R. T., located in Bangkok, Thailand.

Treatments Offered
Superior A.R.T. offers a variety of treatments and state-of-the-art technologies to help couples achieve their dreams of having children. A few of the most common procedures and infertility treatments offered as Superior A.R.T.

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Babies on the Way : Fertility Treatment Options for the 21st Century

by PlacidWay

Infertility is a subject that many couples don’t want to discuss, but it’s an issue that millions of couples around the world deal with on a daily basis. The causes of infertility are numerous, from lack of ovulation to low sperm counts in men. Infertility is not just a woman’s problem, but because of basic anatomy and physiology, women’s ‘plumbing’ so to speak, is more complex and therefore apt to contribute more difficulties to conception than males.

Increase Your Chances of Conception
However, there’s hope on the horizon – new techniques and options in infertility are available not only in the U.S. but also around the world.

Common treatments today include:

• IVF (in vitro fertilization)
• OI (Ovulation induction)
• Clomid treatments
• AI (artificial insemination)
• ICSI (intracytoplasmic sperm injection)
• IUI (intrauterine insemination)
• Alternative Medicines

Whether you’re in your twenties or your forties, couples are finding new techniques to help their dreams of parenthood come true. Most fertility treatments help to increase the development of eggs within the ovary, which help to promote the chances of one of those eggs being fertilized by a sperm. For women who don’t have regular monthly cycles to those who just can’t seem to conceive due to ovulation difficulties, fertility treatments can help.

Treatments with drugs or medications are usually the first step, in an effort to try and stimulate and induce ovulation. These types of drugs are designed for women who have been diagnosed with ovulation difficulties and offers about an 80% success rate. Women who experience difficulties with follicle development, and thereby ovulation problems, may benefit from ovulation induction therapies, where hormones are given to stimulate follicle and egg development.

Intrauterine insemination is generally the next step in the infertility treatment process, also known as artificial insemination. Women experiencing fallopian tube defects or damage, as well as those with poor egg quality often benefit from this type of therapy. At this point, treatments can become quite expensive. Next often comes in vitro fertilization. This involves placement of an already fertilized egg into the woman’s uterus for implantation.

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